Journal
HISTOLOGY AND HISTOPATHOLOGY
Volume 32, Issue 9, Pages 893-898Publisher
F HERNANDEZ
DOI: 10.14670/HH-11-877
Keywords
Psoriasis; RHE; Skin equivalent; IL-17; IL-22; TNF alpha; IFN gamma
Categories
Ask authors/readers for more resources
Psoriasis is a chronic skin disease characterized by the activation of various T cell subsets secreting IFN gamma, IL-17, and IL-22, dendritic cells producing TNF alpha and IFN alpha, and other immune cells including neutrophils and mast cells. Keratinocytes respond to different cytokine signals orchestrating innate and adaptive immune responses. In vitro studies sought to clarify the cytokine effects on keratinocytes in order to evaluate the centrality of these mediators in psoriasis pathogenesis. The aim of this review is to highlight the relevance of this peculiar in vitro approach in investigating cytokine effects on skin or multilayered epidermis. Particularly, we reported keynfindings supporting the cytokine role in psoriasis pathogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available