Journal
COMPTES RENDUS CHIMIE
Volume 20, Issue 5, Pages 559-572Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.crci.2016.09.009
Keywords
Solubility; Modeling; Density-based models; Solid drugs; Supercritical carbon dioxide
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Funding
- Algerian Ministry of Higher Education and Scientific Research (CNEPRU Project) [J0102620110007, J0102620140015]
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A novel density-based model derived by a simple modification of the Jouyban et al. model has been proposed to correlate the solubility of solid drugs in supercritical carbon dioxide. The six-parameter model expresses the solubility only as a function of the solvent density and the equilibrium temperature. This model is in contrast to the Jouyban et al. (J. Superiority. Fluids 24 (2002) 19) model, which gives the solubility as a function of the solvent density and the equilibrium temperature and pressure. The performance of the model has been tested on a database of 100 drugs that account for 2891 experimental data points collected from the literature. The comparison in terms of the mean absolute relative deviation for each solid drug and for the entire database between the proposed model and models that have been suggested to be mostly more accurate demonstrates that the proposed model has the best global correlation performance, exhibiting an overall average absolute relative deviation of 8.13%. (C) 2016 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
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