Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 5, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2017.00019
Keywords
cardiomyocytes; cardiac regeneration; stem cell; biomaterials; cell therapy; electrical stimulation; mechanical stimulation
Categories
Funding
- Heart and Stroke Foundation of Canada [G-14-0006265]
- Canadian Institutes of Health Research [137352, 143066]
- J. P. Bickell foundation [1013821]
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Human pluripotent stem cell-derived cardiomyocytes (hPSC-CM) represent a potential unlimited cell supply for cardiac tissue engineering and possibly regenerative medicine applications. However, hPSC-CMs produced by current protocols are not representative of native adult human cardiomyocytes as they display immature gene expression profile, structure and function. In order to improve hPSC-CM maturity and function, various approaches have been developed, including genetic manipulations to induce gene expression, delivery of biochemical factors, such as triiodothyronine and alpha-adrenergic agonist phenylephrine, induction of cell alignment in 3D tissues, mechanical stress as a mimic of cardiac load and electrical stimulation/pacing or a combination of these. In this mini review, we discuss biomimetic strategies for the maturation for hPSC-CMs with a particular focus on electromechanical conditioning methods.
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