Journal
EUROPEAN EATING DISORDERS REVIEW
Volume 25, Issue 1, Pages 19-25Publisher
WILEY-BLACKWELL
DOI: 10.1002/erv.2486
Keywords
ALSPAC; eating disorders; oxytocin; gene-environment interaction
Categories
Funding
- Wellcome Trust [092731]
- Dowager Countess Eleanor Peel Trust
- NIHR [DHCS/08/08/012]
- Guy's and St Thomas' Charity
- Swiss Anorexia
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [K12HD051959] Funding Source: NIH RePORTER
- Medical Research Council [MC_PC_15018] Funding Source: researchfish
- National Institute for Health Research [CS/08/08/14] Funding Source: researchfish
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This study aimed to investigate associations between oxytocin receptor gene (OXT-R) polymorphisms (rs53576 and rs2254298), their interaction with maternal care (GxE), and ED behaviours in a community sample. We studied 3698 women from the Avon Longitudinal Study of Parents and Children (ALSPAC) who participated in a two-phase prevalence study of lifetime ED and had genotype data. The GG rs53576 genotype was associated with binge eating and purging, and the rs2254298 AG/AA genotype with restrictive eating lifetime. In addition, the rs2254298 AG/AA genotype interacted with poor maternal care to increase the odds of binge eating and purging (odds ratio=4.40 (95% confidence intervals: 1.11-17.4)). This study replicates previous findings of an association between OXT-R polymorphisms and ED, and it is the first to show an interaction between OXT-R genotype and poor maternal care. As such, these findings highlight the important role of oxytocin in understanding the pathophysiology of ED. (c) 2016 The Authors European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd
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