Journal
CASPIAN JOURNAL OF INTERNAL MEDICINE
Volume 8, Issue 4, Pages 228-238Publisher
BABOL UNIV MEDICAL SCIENCES
DOI: 10.22088/cjim.8.4.228
Keywords
Cancer; Immunotherapy; Macrophage activating factor; Gc-MAF; Vitamin D
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Immunotherapy has been used for years in many types of cancer therapy. Recently, cancer immunotherapy has focused on mechanisms which can enhance the development of cell-mediated immunity. Anticancer medications are administered to inhibit immunosuppressive factors such as nagalase enzyme, which is produced by neoplastic cells and destroys macrophage activating factor (Gc-MAF). Anti-neoplastics medications can also enhance immune-cell activity against tumors. Such medications show great potential in cancer immunotherapy using natural human mechanisms against neoplasms.
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