Journal
SLEEP MEDICINE CLINICS
Volume 12, Issue 3, Pages 289-+Publisher
ELSEVIER INC
DOI: 10.1016/j.jsmc.2017.03.005
Keywords
Candidate gene; GWAS; Sleepiness; Sleep; Individual differences; Chronotype; Circadian clock genes; Heritability
Categories
Funding
- Office of Naval Research [N00014-11-1-0361]
- National Aeronautics and Space Administration [NNX14AN49G]
Ask authors/readers for more resources
The circadian clock interacts with the sleep homeostatic drive in humans. Chronotype and sleep parameters show substantial heritability, underscoring a genetic component to these measures. This article reviews the genetic underpinnings of chronotype and of sleep, including sleepiness, sleep quality and latency, and sleep timing and duration in healthy adult sleepers, drawing on candidate gene and genome-wide association studies. Notably, both circadian and noncircadian genes associate with individual differences in chronotype and in sleep parameters. The article concludes with a brief discussion of future research directions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available