Journal
BIOTECHNOLOGY PROGRESS
Volume 29, Issue 6, Pages 1343-1353Publisher
WILEY
DOI: 10.1002/btpr.1792
Keywords
liquid-liquid extraction; aqueous two-phase system; bioparticles; biomolecules
Funding
- FAPESP (Sao Paulo Research Foundation)
- CAPES (National Council for the Improvement of Higher Education)
- CNPq (National Council for Scientific and Technological Development)
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Upstream improvements have led to significant advances in the productivity of biomolecules and bioparticles. Today, downstream processes are the bottleneck in the production of some biopharmaceuticals, a change from previous years. Current purification platforms will reach their physical limits at some point, indicating the need for new approaches. This article reviews an alternative method to extract and purify biomolecules/bioparticles named aqueous two-phase system (ATPS). Biocompatibility and readiness to scale up are some of the ATPS characteristics. We also discuss some of ATPS applications in the biotechnology field. (c) 2013 American Institute of Chemical Engineers Biotechnol. Prog., 29:1343-1353, 2013
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