Journal
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
Volume 97, Issue 3, Pages 767-770Publisher
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.16-0722
Keywords
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Funding
- Tropical Medicine Research Center from the NIH [P50 AI-074321]
- NIH [R01 AI076233, R01 AI045540]
- Council of Scientific and Industrial Research
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [P50AI074321, R01AI076233, R01AI045540] Funding Source: NIH RePORTER
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Visceral leishmaniasis (VL) is a chronic parasitic disease associated with suppressed T cell responses. Although parasites reside intracellularly in macrophages during chronic VL, neutrophils are the first host cell to infiltrate the infection site and phagocytose the parasite. Subsets of neutrophils with unusual characteristics have been documented in human VL, but whether the total neutrophil population is aberrant during disease is not known. Therefore, we examined phenotypic characteristics of unfractionated polymorphonuclear leukocyte (neutrophils) from subjects with active VL, and compared these with neutrophils from healthy controls or subjects who have been treated for VL. The data showed decreased mRNA and diminished amounts of the neutrophil chemoattractant CXCL8 (interleukin [IL]-8), increased IL-10 mRNA and protein, and elevated transcripts encoding arginase-1, which is involved in suppressing T cell responses. Neutrophils from VL subjects showed enhanced capacity to phagocytose Leishmania spp. promastigotes. The results suggest that neutrophils may contribute to immunosuppression in subjects with active VL.
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