Journal
BIOTECHNOLOGY LETTERS
Volume 37, Issue 3, Pages 523-532Publisher
SPRINGER
DOI: 10.1007/s10529-014-1715-y
Keywords
Anti-cancer drug design; Colon cancer cells; E2F2; MicroRNA-31; Proliferation; Survivin; Tumor suppression
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Funding
- National Natural Science Foundation of China [81372331]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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MicroRNA-31 (miR-31) plays important roles in colon cancer development. However, the underlying mechanism is still not clear. We have explored the functions of miR-31 on proliferation of colon cancer cells as well as the underlying mechanism. E2F2 was identified as a direct target of miR-31. miR-31 regulated the proliferation of colon cancer cells by targeting E2F2. Moreover, in the present study, E2F2 acted as a tumor suppressor in colon cancer by repressing the expression of survivin and regulating the expression of CCNA2, C-MYC, MCM4 and CDK2. A possible mechanism for the function of miR-31 on colon cancer proliferation is presented and indicates that miR-31 might become a target for anti-cancer drug design.
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