Journal
BIOTECHNOLOGY LETTERS
Volume 33, Issue 9, Pages 1705-1714Publisher
SPRINGER
DOI: 10.1007/s10529-011-0621-9
Keywords
Bioremediation enhancement; Enhancement of bioproduct production; Oxygen binding and delivery; Oxygen sensing; Vitreoscilla hemoglobin
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The hemoglobin from the bacterium Vitreoscilla (VHb) is the first microbial hemoglobin that was conclusively identified as such (in 1986). It has been extensively studied with respect to its ligand binding properties and mechanisms, structure, biochemical functions, and the mechanisms by which its expression is controlled. In addition, cloning of its gene (vgb) into a variety of heterologous hosts has proved that its expression results substantial increases in production of a variety of useful products and ability to degrade potentially harmful compounds. Recent studies (since 2005) have added significant knowledge to all of these areas and shown the broad range of biotechnological applications in which VHb can have a positive effect.
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