Journal
BIOTECHNOLOGY LETTERS
Volume 33, Issue 3, Pages 469-476Publisher
SPRINGER
DOI: 10.1007/s10529-010-0473-8
Keywords
Aspergillus; Expression platform; Genomics; Systems biology; Genetic engineering; Organelle engineering
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Aspergilli have a long history in biotechnology as expression platforms for the production of food ingredients, pharmaceuticals and enzymes. The achievements made during the last years, however, have the potential to revolutionize Aspergillus biotechnology and to assure Aspergillus a dominant place among microbial cell factories. This mini-review will highlight most recent breakthroughs in fundamental and applied Aspergillus research with a focus on new molecular tools, techniques and products. New trends and concepts related to Aspergillus genomics and systems biology will be discussed as well as the challenges that have to be met to integrate omics data with metabolic engineering attempts.
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