Journal
BIOTECHNOLOGY LETTERS
Volume 32, Issue 11, Pages 1571-1585Publisher
SPRINGER
DOI: 10.1007/s10529-010-0352-3
Keywords
Cell-cell adhesion; Flo1p; Flocculation; FLO genes; Flo proteins; Saccharomyces cerevisiae
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Funding
- Belgian Federal Science Policy Office (Belspo)
- European Space Agency (ESA)
- Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen)
- Research Council of the Vrije Universiteit Brussel
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Cell-cell adhesion occurs in a broad spectrum of biological processes, of which yeast flocculation is an area of interest for evolutionary scientists to brewers and winemakers. The flocculation mechanism is based on a lectin-carbohydrate interaction but is not yet fully understood, although the first model dates back to the 1950s. This review will update the current understanding of the complex mechanism behind yeast flocculation. Moreover, modern technologies to measure the forces involved in single carbohydrate-lectin interactions, are discussed. The Flo1 protein has been extensively described as the protein responsible for strong flocculation. Recently, more research has been directed to the detailed analysis of this flocculin. Due to the advances in the field of bioinformatics, more information about Flo1p could be obtained via structurally or functionally related proteins. Here, we review the current knowledge of the Flo1 protein, with a strong emphasis towards its structure.
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