Journal
BIOTECHNOLOGY LETTERS
Volume 32, Issue 12, Pages 1765-1775Publisher
SPRINGER
DOI: 10.1007/s10529-010-0356-z
Keywords
Biotechnological applications; Cellulase; Function-based approach; Metagenomics; Sequencing
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Funding
- National Natural Science Foundation of China [30960094, 30960013]
- Ministry of Science and Technology of China [2009DFA30700]
- National Hi-tech Research and Development Program of China (863 Program) [2007AA021307]
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Cellulases hydrolyze the beta-1,4 linkages of cellulose and are widely used in food, brewing and wine, animal feed, textiles and laundry, and pulp and paper industries, especially for hydrolyzing cellulosic materials into sugars, which can be fermented to produce useful products such as ethanol. Metagenomics has become an alternative approach to conventional culture-dependent methods as it allows exhaustive mining of microbial genomes in their natural environments. This review covers the current state of research and challenges in mining novel cellulase genes from the metagenomes of various environments, and discusses the potential biotechnological applications of metagenome-derived cellulases.
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