Journal
BIOTECHNOLOGY LETTERS
Volume 33, Issue 2, Pages 321-326Publisher
SPRINGER
DOI: 10.1007/s10529-010-0425-3
Keywords
Biotransformation; Cytochrome P450; Fluorine-19 NMR; Sulfotransferase
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Funding
- Environmental Protection Agency
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Fungi belonging to the genus Cunninghamella have enzymes similar to those employed by mammals for the detoxification of xenobiotics, thus they are useful as models of mammalian drug metabolism, and as a source for drug metabolites. We report the transformation of the anti-cancer drug flutamide in Cunninghamella sp. The most predominant phase I metabolites present in the plasma of humans, 2-hydroxyflutamide and 4-nitro-3-(trifluoromethyl)aniline, were also produced in Cunninghamella cultures. Other phase I and phase II metabolites were also detected using a combination of HPLC, GC-MS and F-19-NMR.
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