Journal
BIOTECHNOLOGY LETTERS
Volume 31, Issue 12, Pages 1817-1824Publisher
SPRINGER
DOI: 10.1007/s10529-009-0099-x
Keywords
Bone morphogenetic proteins; Bone regeneration; Bone repair; Craniofacial surgery; Delivery systems; Orthopaedics
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Funding
- Shriners of North America
- Fonds de la Recherche en Sante du Quebec
- National Science and Engineering Research Council
- Canadian Institutes of Health Research (CIHR)-Regenerative Medicine/Nanomedicine
- Center for Bio-recognition and Biosensors (CBB), McGill University, Montreal, Quebec, Canada
- Center for Bone and Periodontal Diseases Research
- Shriners Hospital, Montreal, Quebec, Canada
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Recombinant human bone morphogenetic proteins (rhBMPs) have been extensively investigated for developing therapeutic strategies aimed at the restoration and treatment of orthopaedic as well as craniofacial conditions. In this first part of the review, we discuss the rationale for the necessary use of carrier systems to deliver rhBMP-2 and rhBMP-7 to sites of bone tissue regeneration and repair. General requirements for growth factor delivery systems emphasizing the distinction between localized and release-controlled delivery strategies are presented highlighting the current limitations in the development of an effective rhBMP delivery system applicable in clinical bone tissue engineering.
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