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Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering

Journal

BIOTECHNOLOGY LETTERS
Volume 31, Issue 12, Pages 1825-1835

Publisher

SPRINGER
DOI: 10.1007/s10529-009-0100-8

Keywords

Biomaterials; Bone morphogenetic proteins; Bone regeneration; Controlled-release; Nanoparticles; Synthetic polymers

Funding

  1. Shriners of North America
  2. Fonds de la Recherche en Sante du Quebec
  3. National Science and Engineering Research Council
  4. Canadian Institutes of Health Research (CIHR)-Regenerative Medicine/Nanomedicine
  5. Center for Biorecognition and Biosensors (CBB), McGill University, Montreal, Quebec, Canada
  6. Center for Bone and Periodontal Diseases Research
  7. Shriners Hospital, Montreal, Quebec, Canada

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Localized and release-controlled delivery systems for the sustained expression of the biologic potency of rhBMPs are essential. A substantial number of biomaterials have been investigated thus far. Most fail after implantation or administration mainly due to either being too soft, difficult to control and/or stabilize mechanically. In the second part of this review, we review a representative selection of rhBMP-2 and rhBMP-7 carrier materials and delivery systems ranging from simple nano/microparticles to complex 3-D scaffolds in sites of orthopaedic and craniofacial bone regeneration and repair.

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