Journal
BIOTECHNOLOGY LETTERS
Volume 31, Issue 12, Pages 1825-1835Publisher
SPRINGER
DOI: 10.1007/s10529-009-0100-8
Keywords
Biomaterials; Bone morphogenetic proteins; Bone regeneration; Controlled-release; Nanoparticles; Synthetic polymers
Categories
Funding
- Shriners of North America
- Fonds de la Recherche en Sante du Quebec
- National Science and Engineering Research Council
- Canadian Institutes of Health Research (CIHR)-Regenerative Medicine/Nanomedicine
- Center for Biorecognition and Biosensors (CBB), McGill University, Montreal, Quebec, Canada
- Center for Bone and Periodontal Diseases Research
- Shriners Hospital, Montreal, Quebec, Canada
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Localized and release-controlled delivery systems for the sustained expression of the biologic potency of rhBMPs are essential. A substantial number of biomaterials have been investigated thus far. Most fail after implantation or administration mainly due to either being too soft, difficult to control and/or stabilize mechanically. In the second part of this review, we review a representative selection of rhBMP-2 and rhBMP-7 carrier materials and delivery systems ranging from simple nano/microparticles to complex 3-D scaffolds in sites of orthopaedic and craniofacial bone regeneration and repair.
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