Journal
BIOTECHNOLOGY LETTERS
Volume 32, Issue 3, Pages 373-378Publisher
SPRINGER
DOI: 10.1007/s10529-009-0165-4
Keywords
Inflammation; NF-kappa B; Oxidative stress; gamma-Irradiation; Signaling
Categories
Funding
- Korea government (MEST) [2007-00376, 2009-0083538]
- National Research Foundation of Korea [2007-00376] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
The effects of gamma-irradiation on inflammatory gene expression, including NF-kappa B activation, in the kidney of C57/BL6 mice exposed to 1-9 Gy doses of Co-60 gamma-irradiation. Radiation enhanced the NF-kappa B activation and oxidative stress caused a dose-dependent disruption in the redox balance. The significance of this study is the new molecular information gained on gamma-irradiation effects through the activation of pro-inflammatory genes by NF-kappa B via the MAPK signaling pathway. Considering the exquisite sensitivity of NF-kappa B and other pro-inflammatory mediators to the redox status, we conclude that the activation of inflammatory processes by irradiation is likely initiated by increased oxidative stress.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available