Journal
BIOTECHNOLOGY LETTERS
Volume 32, Issue 1, Pages 45-51Publisher
SPRINGER
DOI: 10.1007/s10529-009-0117-z
Keywords
Apoptotic cell death; 1,3-Dichloro-2-propanol; NF-kappa B; Reactive oxygen species
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Funding
- Ministry of Education and Human Resources Development, Republic of Korea.
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We demonstrated that the apoptotic cell death of mouse melanoma cells exposed to 1,3-dichloro-2-propanol (DCP) was Ca2+ dependent. 1,3-DCP inhibited the growth of mouse melanoma cells in a concentration-dependent manner. Furthermore, a terminal nick-end labeling of fragmented DNA (TUNEL) assay demonstrated that 1,3-DCP-induced apoptosis. Moreover, reactive oxygen species and Ca2+, generated by mouse melanoma cells that were exposed to 1,3-DCP, resulted in the activation of NF-kappa B and MAPKs. Finally, treatment with BAPTA, an intracellular Ca2+ chelator, completely inhibited the apoptosis that was induced by 1,3-DCP treatment of B16F10 cells.
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