Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 1000, Issue -, Pages 169-175Publisher
ELSEVIER
DOI: 10.1016/j.jchromb.2015.07.016
Keywords
Electra-enhanced solid-phase microextraction; Ordered mesoporous carbon/Nafion coated fiber; Amphetamines; Urine and serum samples; Gas chromatography-flame thermionic detection
Funding
- National Nature Scientific Foundations of China [21105123]
- Fundamental Research Funds for the Central Universities [14CX02216A, 15CX02070A]
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In this work, an ordered mesoporous carbon (OMC)/Nafion coated fiber for solid-phase microextraction (SPME) was prepared and used as the working electrode for electro-enhanced SPME (EE-SPME) of amphetamines. The EE-SPME strategy is primarily based on the electro-migration and complementary charge interaction between fiber coating and ionic compounds. Compared with traditional SPME, EE-SPME exhibited excellent extraction efficiency for amphetamine (AP) and methamphetamine (MA) with an enhancement factor of 7.8 and 12.1, respectively. The present strategy exhibited good linearity for the determination of AP and MA in urine samples in the range of 10-1000 ngmL(-1) and 20-1000 ng mL(-1), respectively. The detection limits were found to be 1.2 ng mL(-1) for AP and 4.8 ng mL(-1) for MA. The relative standard deviations were calculated to be 6.2% and 8.5% for AP and MA, respectively. Moreover, the practical application of the proposed method was demonstrated by analyzing the amphetamines in urine and serum samples with satisfactory results. (C) 2015 Elsevier B.V. All rights reserved.
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