Journal
BIOTECHNOLOGY JOURNAL
Volume 9, Issue 5, Pages 609-620Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/biot.201300445
Keywords
Industrial biotechnology; Metabolic engineering; Saccharomyces cerevisiae; Synthetic biology; Yeast
Funding
- Novo Nordisk Foundation
- NNF Center for Biosustainability [Yeast Metabolic Engineering] Funding Source: researchfish
- Novo Nordisk Fonden [NNF10CC1016517] Funding Source: researchfish
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Yeast Saccharomyces cerevisiae is an important industrial host for production of enzymes, pharmaceutical and nutraceutical ingredients and recently also commodity chemicals and biofuels. Here, we review the advances in modeling and synthetic biology tools and how these tools can speed up the development of yeast cell factories. We also present an overview of metabolic engineering strategies for developing yeast strains for production of polymer monomers: lactic, succinic, and cis,cis-muconic acids. S. cerevisiae has already firmly established itself as a cell factory in industrial biotechnology and the advances in yeast strain engineering will stimulate development of novel yeast-based processes for chemicals production.
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