Journal
BIOTECHNOLOGY JOURNAL
Volume 8, Issue 11, Pages 1267-1279Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/biot.201200386
Keywords
Biomarker; Biosensor; Microfluidics; Point-of-care diagnostic
Funding
- Indian Council of Medical Research, India [ICMR/5/3/8/91/GM/2010-RHN]
- Department of Science and Technology, India [DST/TSG/ME/2008/18]
- Delhi Technological University
- Council of Scientific & Industrial Research India
- Chungnam National University, Daejeon, Korea under World Class University Project of the Ministry of Education, Science and Technology of Korea [R32-20026]
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There is a growing demand to integrate biosensors with microfluidics to provide miniaturized platforms with many favorable properties, such as reduced sample volume, decreased processing time, low cost analysis and low reagent consumption. These microfluidics-integrated biosensors would also have numerous advantages such as laminar flow, minimal handling of hazardous materials, multiple sample detection in parallel, portability and versatility in design. Microfluidics involves the science and technology of manipulation of fluids at the micro- to nano-liter level. It is predicted that combining biosensors with microfluidic chips will yield enhanced analytical capability, and widen the possibilities for applications in clinical diagnostics. The recent developments in microfluidics have helped researchers working in industries and educational institutes to adopt some of these platforms for point-of-care (POC) diagnostics. This review focuses on the latest advancements in the fields of microfluidic biosensing technologies, and on the challenges and possible solutions for translation of this technology for POC diagnostic applications. We also discuss the fabrication techniques required for developing microfluidic-integrated biosensors, recently reported biomarkers, and the prospects of POC diagnostics in the medical industry.
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