Journal
BIOTECHNOLOGY JOURNAL
Volume 6, Issue 9, Pages 1064-1070Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/biot.201100086
Keywords
Flux optimization; Metabolic engineering; Synthetic biology; Tuning of gene expression
Funding
- Synthetic Biology Engineering Research Center (SynBERC)
- National Science Foundation [EEC-0540879, CBET-0954986]
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0954986] Funding Source: National Science Foundation
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With increasing price volatility and growing awareness of the lack of sustainability of traditional chemical synthesis, microbial chemical production has been tapped as a promising renewable alternative for the generation of diverse, stereospecific compounds. Nonetheless, many attempts to generate them are not yet economically viable. Due to the zero-sum nature of microbial resources, traditional strategies of pathway optimization are attaining minimal returns. This result is in part a consequence of the gross changes in host physiology resulting from such efforts and underscores the need for more precise and subtle forms of gene modulation. In this review, we describe alternative strategies and emerging paradigms to address this problem and highlight potential solutions from the emerging field of synthetic biology.
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