Journal
BIOTECHNOLOGY JOURNAL
Volume 7, Issue 5, Pages 649-655Publisher
WILEY-BLACKWELL
DOI: 10.1002/biot.201100203
Keywords
Arthrospira (Spirulina) platensis; Fed-batch process; Microbial biomass; Potassium nitrate; Urea
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Fapesp) [2005/52255-6, 2005/52269-7]
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Urea has been considered as a promising alternative nitrogen source for the cultivation of Arthrospira platensis if it is possible to avoid ammonia toxicity; however, this procedure can lead to periods of nitrogen shortage. This study shows that the addition of potassium nitrate, which acts as a nitrogen reservoir, to cultivations carried out with urea in a fed-batch process can increase the maximum cell concentration (Xm) and also cell productivity (PX). Using response surface methodology, the model indicates that the estimated optimum Xm can be achieved with 17.3 mM potassium nitrate and 8.9 mM urea. Under this condition an Xm of 6077 +/- 199 mg/L and a PX of 341.5 +/- 19.1 mg L1day1 were obtained.
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