Journal
ANNALS OF TRANSLATIONAL MEDICINE
Volume 6, Issue 15, Pages -Publisher
AME PUBL CO
DOI: 10.21037/atm.2018.06.34
Keywords
Hypertension; cardiovascular disease; genetics; risk score; pharmacogenetics; gene-environment
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Funding
- British Heart Foundation [FS/12/82/29736] Funding Source: Medline
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Hypertension continues to be a major risk factor for global mortality, and recent genomewide association studies (GWAS) have expanded in size, leading to the identification of further genetic loci influencing blood pressure. In light of the new knowledge from the largest cardiovascular GWAS to date, we review the potential impact of genomics on discovering potential drug targets, risk stratification with genetic risk scores, drug selection with pharmacogenetics, and exploring insights provided by gene-environment interactions.
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