Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 360, Issue 3, Pages 468-473Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201701364
Keywords
Methylsulfoxidation; Tetrazole-amines; tert-butyl Nitrite; Methylsulfinyl-1H-tetrazole; Antifungal Activity
Categories
Funding
- Fundamental Research Funds for the Central Universities (NJAU) [KYTZ201604]
- Foundation Research Project of Jiangsu Province (The Natural Science Foundation) [BK20141359]
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A tert-butyl nitrite mediated methylsulfoxidation of tetrazole-amines in neat DMSO or methyl-sulfinyl derivatives is revealed for the first time. The reaction exhibits good group tolerance, as well as highly selectivity to sulfinyl substitutions. This new protocol provides an expeditious and operationally simple procedure for C-S(O) bond construction. Preliminary bioactivity evaluation on selected products shows promising antifungal activities.
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