Journal
CELLULOSE
Volume 25, Issue 1, Pages 559-571Publisher
SPRINGER
DOI: 10.1007/s10570-017-1546-9
Keywords
Self-healing; Injectable polysaccharide hydrogel; Cellulose nanocrystals; Enamine bond
Funding
- National Natural Science Foundation of China [51403035]
- Natural Science Foundation of Inner Mongolia [2015MS0209]
- Fundamental Research Funds for the Central Universities [15D110510]
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An injectable polysaccharide hydrogel based on cellulose acetoacetate (CAA), hydroxypropyl chitosan (HPCS), and amino-modified cellulose nanocrystals (CNC-NH2) was prepared under physiological conditions. CNC-NH2 acted as both physical and chemical cross-linker. The effects of CNC-NH2 loading on the mechanical properties, internal morphology and gelation time were investigated; the maximum storage modulus was observed for a gel containing 0.80 wt% of CNC-NH2. The structure and properties of the polysaccharide hydrogel were characterized by Fourier-transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, scanning electron microscopy, Raman spectroscopy and rheology testing. The polysaccharide hydrogel exhibited pH- responsive properties and excellent stability under physiological conditions. The hydrogel also exhibited self-healing behavior under acidic conditions via enamine bond exchange. In addition, CCK-8 cytotoxicity study with fibroblast L929 cells demonstrates good biocompatibility of CNCs reinforced hydrogels.
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