Journal
BIOTECHNOLOGY AND BIOENGINEERING
Volume 111, Issue 9, Pages 1699-1716Publisher
WILEY
DOI: 10.1002/bit.25307
Keywords
albumin; drug delivery; erythrocyte; exosome; Fc fusion; folic acid; lipoprotein; macrophage; platelet; transferrin
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Funding
- NIH [NIH R01 EB-00188, NIH R01 EB007205]
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The goal of drug delivery is to improve the safety and therapeutic efficacy of drugs. This review focuses on delivery platforms that are either derived from endogenous pathways, long-circulating biomolecules and cells or that piggyback onto long-circulating biomolecules and cells. The first class of such platforms is protein-based delivery systems-albumin, transferrin, and fusion to the Fc domain of antibodies-that have a long-circulation half-life and are designed to transport different molecules. The second class is lipid-based delivery systems-lipoproteins and exosomes-that are naturally occurring circulating lipid particles. The third class is cell-based delivery systems-erythrocytes, macrophages, and platelets-that have evolved, for reasons central to their function, to exhibit a long life-time in the body. The last class is small molecule-based delivery systems that include folic acid. This article reviews the biology of these systems, their application in drug delivery, and the promises and limitations of these endogenous systems for drug delivery. (c) 2014 Wiley Periodicals, Inc.
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