Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1400, Issue -, Pages 10-18Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2015.04.061
Keywords
Core-shell magnetic microsphere; Metal-organic frameworks; Domoic acid; Magnetic solid-phase extraction; HPLC-MS/MS
Funding
- National Nature Sciences Foundation of China [21275029, 21405018]
- National Basic Research Program of China [2010CB732403]
- Five-twelfth National Science and Technology Support Program [2012BAD29B06]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1116]
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Fe3O4@SiO2@UiO-66 core-shell magnetic microspheres were synthesized and characterized by transmission electron microscopy, scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectrometry, vibrating sample magnetometry, nitrogen adsorption porosimetry and zeta potential analyzer. The synthesized Fe3O4@SiO2@UiO-66 microspheres were first used for magnetic solid-phase extraction (MSPE) of domoic acid (DA) in shellfish samples. Combined with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), a fast, simple and sensitive method for the determination of DA was established successfully. Under the optimized conditions, the developed method showed short analysis time, good linearity (r(2) = 0.9990), low limit of detection (1.45 pg mL(-1); S/N = 3:1), low limit of quantification (4.82 pg mL(-1); S/N = 10:1), and good extraction repeatability (RSD <= 5.0%; n = 5). Real shellfish samples were processed using the developed method, and trace level of DA was detected. The results demonstrate that Fe3O4@SiO2@UiO-66 core-shell magnetic microspheres are the promising sorbents for rapid and efficient extraction of polar analytes from complex biological samples. (C) 2015 Elsevier B.V. All rights reserved.
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