Journal
BIOTECHNOLOGY AND BIOENGINEERING
Volume 110, Issue 1, Pages 327-337Publisher
WILEY
DOI: 10.1002/bit.24615
Keywords
ACL fibroblasts; alignment; dopamine; RGD; type I collagen
Categories
Funding
- National Science Council, Taiwan [100-2221-E-002-114-MY2]
Ask authors/readers for more resources
This study aimed to investigate the effects of submicron-grooved topography and surface cell affinity on the attachment, proliferation and collagen synthesis of anterior cruciate ligament (ACL) cells. Two grooved polystyrene (PS) surfaces (equal groove/ridge width of 800?nm) with a groove depth of 100 or 700?nm were fabricated and modified by oxygen plasma treatment, dopamine deposition and conjugation of RGD-containing peptides to enhance cell affinity. The elongation and alignment of ACL cells was enhanced by grooved structures with increasing groove depths regardless of surface chemistry. On the other hand, cell spreading and proliferation mainly depended on surface chemistry, in accordance with surface cell affinity: O2 plasma?
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available