Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1377, Issue -, Pages 13-26Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2014.12.041
Keywords
Microfluidic; Infectious disease; Point-of-care testing; Immunoassay; Nucleic acid analysis
Funding
- Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
- China Postdoctoral Science Foundation [2012M520650]
- Special Fund for Agro-scientific Research in the Public Interest [20130345]
- Key Projects in the National Science & Technology Pillar Program in the Twelfth Five-year Plan Period of China [2012BAK02B00, 2012BAK02B03]
Ask authors/readers for more resources
Rapid and timely diagnosis of infectious diseases is a critical determinant of clinical outcomes and general public health. For the detection of various pathogens, microfluidics-based platforms offer many advantages, including speed, cost, portability, high throughput, and automation. This review provides an overview of the recent advances in microfluidic technologies for point-of-care (POC) diagnostics for infectious diseases. The key aspects of such technologies for the development of a fully integrated POC platform are introduced, including sample preparation, on-chip nucleic acid analysis and immunoassay, and system integration/automation. The current challenges to practical implementation of this technology are discussed together with future perspectives. (C) 2014 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
