Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1382, Issue -, Pages 48-64Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2014.12.086
Keywords
Microdialysis; Electrophoresis; Microfluidics; Sensor; Lab-on-a-chip; Electrochemical detection
Funding
- National Institutes of Health [R01 NS042929]
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Microdialysis is a powerful sampling technique that enables monitoring of dynamic processes in vitro and in vivo. The combination of microdialysis with chromatographic or electrophoretic methods with selective detection yields a separation-based sensor capable of monitoring multiple analytes in near real time. For monitoring biological events, analysis of microdialysis samples often requires techniques that are fast (<1 min), have low volume requirements (nL-pL), and, ideally, can be employed on-line. Microchip electrophoresis fulfills these requirements and also permits the possibility of integrating sample preparation and manipulation with detection strategies directly on-chip. Microdialysis coupled to microchip electrophoresis has been employed for monitoring biological events in vivo and in vitro. This review discusses technical considerations for coupling microdialysis sampling and microchip electrophoresis, including various interface designs, and current applications in the field. (C) 2015 Elsevier B.V. All rights reserved.
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