Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1382, Issue -, Pages 98-116Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2014.10.039
Keywords
Proteomics; Metabolomics; Lab-on-a-chip; Integrated devices; Bioanalysis
Funding
- National Institutes of Health [R01 DK080714]
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Microfluidic devices offer great advantages in integrating sample processes, minimizing sample and reagent volumes, and increasing analysis speed, while mass spectrometry detection provides high information content, is sensitive, and can be used in quantitative analyses. The coupling of microfluidic devices to mass spectrometers is becoming more common with the strengths of both systems being combined to analyze precious and complex samples. This review summarizes select achievements published between 2010 and July 2014 in novel coupling between microfluidic devices and mass spectrometers. The review is subdivided by the types of ionization sources employed, and the different microfluidic systems used. (C) 2014 Elsevier BM. All rights reserved.
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