4.6 Article

A Mechanistic Understanding of Production Instability in CHO Cell Lines Expressing Recombinant Monoclonal Antibodies

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

Cell Line-Specific Control of Recombinant Monoclonal Antibody Production by CHO Cells

Peter M. O'Callaghan et al.

BIOTECHNOLOGY AND BIOENGINEERING (2010)

Article Biotechnology & Applied Microbiology

Strategies for Selecting Recombinant CHO Cell Lines for cGMP Manufacturing: Improving the Efficiency of Cell Line Generation

Alison J. Porter et al.

BIOTECHNOLOGY PROGRESS (2010)

Article Biotechnology & Applied Microbiology

DNA methylation contributes to loss in productivity of monoclonal antibody-producing CHO cell lines

Yuansheng Yang et al.

JOURNAL OF BIOTECHNOLOGY (2010)

Review Multidisciplinary Sciences

Functional roles for noise in genetic circuits

Avigdor Eldar et al.

NATURE (2010)

Article Medicine, Research & Experimental

DNA methylation and gene expression

Zahava Siegfried et al.

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2010)

Article Biotechnology & Applied Microbiology

Detailed Understanding of Enhanced Specific Antibody Productivity in NS0 Myeloma Cells

Soo Hean Gary Khoo et al.

BIOTECHNOLOGY AND BIOENGINEERING (2009)

Article Biotechnology & Applied Microbiology

A Study of Monoclonal Antibody-Producing CHO Cell Lines: What Makes a Stable High Producer?

Janet Chusainow et al.

BIOTECHNOLOGY AND BIOENGINEERING (2009)

Article Biochemistry & Molecular Biology

CpG islands - 'A rough guide'

Robert S. Illingworth et al.

FEBS LETTERS (2009)

Review Genetics & Heredity

Mechanisms of change in gene copy number

P. J. Hastings et al.

NATURE REVIEWS GENETICS (2009)

Review Biochemistry & Molecular Biology

Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin?

T. Clouaire et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

Article Biotechnology & Applied Microbiology

The bisulfite genomic sequencing used in the analysis of epigenetic states, a technique in the emerging environmental genotoxicology research

Hikoya Hayatsu

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2008)

Review Immunology

Role of the cytomegalovirus major immediate early enhancer in acute infection and reactivation from latency

Mark F. Stinski et al.

MEDICAL MICROBIOLOGY AND IMMUNOLOGY (2008)

Article Biotechnology & Applied Microbiology

Molecular analysis of successful cell line selection in transfected GS-NS0 myeloma cells

Louise M. Barnes et al.

BIOTECHNOLOGY AND BIOENGINEERING (2007)

Article Multidisciplinary Sciences

Human cancers express a mutator phenotype

Jason H. Bielas et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Biochemistry & Molecular Biology

Toward more efficient protein expression

Stephan Kalwy et al.

MOLECULAR BIOTECHNOLOGY (2006)

Review Pharmacology & Pharmacy

Antibody production

John R. Birch et al.

ADVANCED DRUG DELIVERY REVIEWS (2006)

Article Biotechnology & Applied Microbiology

Phenotypic variation during cloning procedures: Analysis of the growth behavior of clonal cell lines

Louise M. Barnes et al.

BIOTECHNOLOGY AND BIOENGINEERING (2006)

Article Biochemistry & Molecular Biology

Genetic characterization of CHO production host DG44 and derivative recombinant cell lines

M Derouazi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)

Review Biochemistry & Molecular Biology

Genomic DNA methylation: the mark and its mediators

RJ Klose et al.

TRENDS IN BIOCHEMICAL SCIENCES (2006)

Article Biotechnology & Applied Microbiology

On the optimal ratio of heavy to light chain genes for efficient recombinant antibody production by CHO cells

S Schlatter et al.

BIOTECHNOLOGY PROGRESS (2005)

Article Biotechnology & Applied Microbiology

Diverse plasmid DNA vectors by directed molecular evolution of cytomegalovirus promoters

A Wright et al.

HUMAN GENE THERAPY (2005)

Article Biotechnology & Applied Microbiology

Uncoupling of cell growth and proliferation results in enhancement of productivity in p21C1P1-arrested CHO cells

JX Bi et al.

BIOTECHNOLOGY AND BIOENGINEERING (2004)

Article Biotechnology & Applied Microbiology

Molecular definition of predictive indicators of stable protein expression in recombinant NSO myeloma cells

LM Barnes et al.

BIOTECHNOLOGY AND BIOENGINEERING (2004)

Review Biotechnology & Applied Microbiology

Production of recombinant protein therapeutics in cultivated mammalian cells

FM Wurm

NATURE BIOTECHNOLOGY (2004)

Article Biochemistry & Molecular Biology

Control of cytomegalovirus lytic gene expression by histone acetylation

JC Murphy et al.

EMBO JOURNAL (2002)

Review Biochemistry & Molecular Biology

Methyl CpG-binding transcriptional proteins and repression

PA Wade

BIOESSAYS (2001)

Article Biotechnology & Applied Microbiology

Characterization of the stability of recombinant protein production in the GS-NS0 expression system

LM Barnes et al.

BIOTECHNOLOGY AND BIOENGINEERING (2001)

Article Multidisciplinary Sciences

CPG methylation as a mechanism for the regulation of E2F activity

MR Campanero et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Biotechnology & Applied Microbiology

Amplified gene location in chromosomal DNA affected recombinant protein production and stability of amplified genes

Y Yoshikawa et al.

BIOTECHNOLOGY PROGRESS (2000)