Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1394, Issue -, Pages 103-110Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2015.03.054
Keywords
Organic monolith; Thiol-ene click reaction; Capillary liquid chromatography; Photo-initiated polymerization; 1,2,4-Trivinylcyclohexane
Funding
- China State Key Basic Research Program Grant [2013CB911203, 2012CB910601]
- National Natural Sciences Foundation of China [21235006, 21175133]
- Creative Research Group Project of NSFC [21321064]
- Hundred Talents Program of the Dalian Institute of Chemical Physics of Chinese Academy of Sciences
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A novel organic monolith was firstly prepared in a UV-transparent fused-silica capillary by a single-step approach via photo-initiated thiol-ene click polymerization reaction of 1,2,4-trivinylcyclohexane (TVCH) and pentaerythriol tetra(3-mercaptopropionate) (4SH) within 10 min. The effects of both composition of prepolymerization solution and polymerization time on the morphology and permeability of monolithic column were investigated in detail. Then, the optimal condition was acquired to fabricate a homogeneous and permeable organic monolith. The chemical groups of the monolithic column were confirmed by Fourier transform infrared spectroscopy (FT-IR). The SEM graphs showed the organic monolith possessed a uniform porous structure, which promotes the highest column efficiency of 133,000 plates per meter for alkylbenzenes at the linear velocity of 0.65 mm/s in reversed-phase liquid chromatography. Finally, the organic monolithic column was further applied for separation of basic compounds, pesticides and EPA610, indicating satisfactory separation ability. (C) 2015 Elsevier B.V. All rights reserved.
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