Journal
BIOTECHNOLOGY AND BIOENGINEERING
Volume 106, Issue 5, Pages 699-706Publisher
WILEY-BLACKWELL
DOI: 10.1002/bit.22775
Keywords
biocatalysis; cytochrome P450; drug development
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Cytochrome P450 monooxygenases (CYPs) are important enzymes in the metabolism of xenobiotics. Therefore, several approaches to clone and overexpress the human isoforms have been made. In addition to microsomes or S9 preparations, these recombinant human isoforms have found diverse application in drug development. We discuss and give examples of the use of bacterial whole cell systems with rec. human CYPs for the preparative scale synthesis of drug metabolites. Biotechnol. Bioeng. 2010;106: 699-706. (C) 2010 Wiley Periodicals, Inc.
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