Journal
THERANOSTICS
Volume 8, Issue 21, Pages 6053-6069Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.30305
Keywords
Rho-associated coiled-coil kinase (ROCK); angiogenesis; endothelial cell; microenvironment; therapeutic target
Categories
Funding
- Cancer Prevention and Research Institute of Texas [RR140081, RR170721]
- National Natural Science Foundation of China [81700319, 81570255]
- Key Science and Technology Research Plan of Shandong Province [2017GSF218037]
- Shandong Taishan Scholarship
Ask authors/readers for more resources
Identified as a major downstream effector of the small GTPase RhoA, Rho-associated coiled-coil kinase (ROCK) is a versatile regulator of multiple cellular processes. Angiogenesis, the process of generating new capillaries from the pre-existing ones, is required for the development of various diseases such as cancer, diabetes and rheumatoid arthritis. Recently, ROCK has attracted attention for its crucial role in angiogenesis, making it a promising target for new therapeutic approaches. In this review, we summarize recent advances in understanding the role of ROCK signaling in regulating the permeability, migration, proliferation and tubulogenesis of endothelial cells (ECs), as well as its functions in non-ECs which constitute the pro-angiogenic microenvironment. The therapeutic potential of ROCK inhibitors in angiogenesis-related diseases is also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available