Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1377, Issue -, Pages 1-12Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2014.12.032
Keywords
Acid dissociation constant; Capillary electrophoresis; Chiral separation; Cosolvent systems; Migration order reversal; pK(a)-shift
Funding
- Krakowskie Konsorcjum Materia-Energia-Przyszlosc within the subsidy KNOW
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The chemical groups undergoing protonation or deprotonation in solution are described by the acid dissociation constant value, the key parameter for physicochemical characterization of biologically- and pharmacologically-important compounds. Capillary electrophoresis (CE) proved to be suitable technique for its determination: it enables automated and accurate measurements even for minute amount of sample, does not require the information about concentration, and handle both the impure and complex samples. In this review, a number of contributions reporting on the application of CE in pK(a) prediction has been summarized and critically discussed. The reader will find herein the brief introduction of theory, summary of all works published in the last decade, considerations on the most important innovations and achievements, and the discussion of pK(a)-related issues as e.g. the role of pK(a)-shifts in the chiral separation mechanism or the elucidation of migration order reversals observed during CE-mediated separations. (C) 2014 Elsevier B.V. All rights reserved.
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