Journal
BIOTECHNOLOGY AND BIOENGINEERING
Volume 101, Issue 4, Pages 850-858Publisher
WILEY
DOI: 10.1002/bit.21952
Keywords
boron nitride nanotubes; biocompatibility; quantum dots; cell uptake; endocytosis
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Funding
- IIT (Italian Institute of Technology) Network
- NINIVE (Non-Invasive Nanotransducer for In Vivo gene thErapy [STRP 033378]
- 6FP of the European Commission
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Boron nitride nanotubes (BNNTs) have unique physical properties, which can be exploited in the biomedical field. Hence, the surprising lack of reported studies on their biocompatibility and interactions with living cells, addressed by the present paper which deals the results of such an investigation based on 72 h culture of human neuroblastoma cell line (SH-SY5Y) in the presence of an aqueous suspension of polyethyleneimine (PEI)-coated BNNTs. BNNTs conjugated with fluorescent markers (quantum dots) are employed to enable tracking of their uptake by living cells. The results demonstrate good cyto-compatibility together with unequivocal BNNT cellular uptake by an energy-dependent endocytic process.
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