Journal
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
Volume 61, Issue 6, Pages 646-654Publisher
WILEY
DOI: 10.1002/bab.1222
Keywords
lignin; phenylpropanoids; p-coumaryl alcohol; metabolic engineering; Escherichia coli
Funding
- German Federal Ministry of Education and Research
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The plant polymer lignin is the greatest source of aromatic chemical structures on earth. Hence, the chemically diverse lignin monomers are valuable raw materials for fine chemicals, materials synthesis, and food and flavor industries. However, extensive use of this natural resource is hampered by the large number of different lignin monomers and the complex and irregular structure of lignin, which renders current processes for its chemical or enzymatic degradation inefficient. The microbial production of lignin monomers from renewable resources represents a promising alternative to lignin degradation, which could meet the demand for aromatic chemical structures. In this study, we describe the functional introduction of an artificial phenylpropanoid pathway into Escherichia coli, achieved by transferring several genes from plants and microbes. The established chimeric pathway efficiently converts L-tyrosine into the lignin precursor molecule p-coumaryl alcohol. (c) 2014 International Union of Biochemistry and Molecular Biology, Inc.
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