Journal
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
Volume 58, Issue 1, Pages 58-67Publisher
WILEY
DOI: 10.1002/bab.6
Keywords
plant-made pharmaceuticals; plant biologic production; bioprocessing; clinical trials; biosimilars
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The number of approaches to recombinant protein production in plants is greater than ever before. Development of these new and improved technologies as production platforms for plant-made pharmaceuticals has and will continue to create new commercial opportunities in the pharmaceutical sector. However, it is inevitable that no single system will be optimal for the production of all recombinant proteins of interest in plants due to both the physical characteristics and the envisaged therapeutic application of each product. Here, we review a range of promising product/platform pairs emphasizing synergies during production and in clinical trials.
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