Journal
BIOTECHNOLOGY ADVANCES
Volume 36, Issue 8, Pages 2101-2117Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2018.09.005
Keywords
Butyric acid; Clostridia; Fermentation; Metabolic engineering; Product recovery; Renewable feedstock
Categories
Funding
- Department of Energy [DE-EE0007005]
- Advanced Research Projects Agency Energy [DE-AR0000095]
- National Science Foundation STTR program [IIP-1026648]
- Ohio Department of Development-Third Frontier Advanced Energy Program [Tech 08-036]
- National Science Foundation of China [21676098, U1603112]
- Natural Science Foundation of Jiangsu Province [BK20171461]
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Butyric acid is an important C4 organic acid with broad applications. It is currently produced by chemosynthesis from petroleum-based feedstocks. However, the fermentative production of butyric acid from renewable feedstocks has received growing attention because of consumer demand for green products and natural ingredients in foods, pharmaceuticals, animal feed supplements, and cosmetics. In this review, strategies for improving microbial butyric acid production, including strain engineering and novel fermentation process development are discussed and compared regarding product yield, titer, purity and productivity. Future perspectives on strain and process improvements for butyric acid production are also discussed.
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