Journal
BIOTECHNOLOGY ADVANCES
Volume 36, Issue 6, Pages 1779-1799Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2017.11.003
Keywords
Phytochemicals; Polyphenols; miRNAs; ncRNAs; Natural products; MDR; Cancer
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Funding
- POC grant entitled Clinical and economical impact of personalized targeted anti-microRNA therapies in reconverting lung cancer chemoresistance - CANTEMIR [35/01.09.2016, ID 37_796]
- NanoLALand, PhD fellowship (PCD) [1300/29/13.01.2017]
- Project Transcriptional assay in oral cancer - Medical University of Plovdiv [HO -18/2014]
- Polish KNOW (Leading National Research Centre) Scientific Consortium Healthy Animal-Safe Food, decision of Ministry of Science and Higher Education [05-1/KNOW2/2015]
- [7BM/2016]
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current trend of combining state of the art technologies with quondam treatments in order to overcome existing gaps in the clinical area determined an increased interest into polyphenols, common dietary phytochemicals, for the prevention and treatment of chronic diseases, especially cancer. The reemergence of poly phenols in the cancer field is sustained by advanced-omits technologies able to identify coding and non-coding genes and their related signaling pathways modulated by natural compounds. Identification of the structural correspondence between interacting molecules will allow the development of more targeted and informed therapeutic strategies for cancer management.
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