Journal
BIOTECHNOLOGY ADVANCES
Volume 32, Issue 2, Pages 485-491Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2014.01.001
Keywords
Photoreceptor; Transplantation; Gliosis; Degeneration; Stem cells; Eye; Visual function; Development; Neural retina
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Funding
- Medical Research Council [G03000341, mr/j004553/1, 6HAT/DENR]
- Wellcome Trust [086128/Z/08/Z]
- BBSRC [BB/I013636/1]
- RP Fighting Blindness [GR566]
- Fight for Sight [1448/1449]
- BBSRC [BB/I013636/1] Funding Source: UKRI
- MRC [MR/J004553/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I013636/1] Funding Source: researchfish
- Fight for Sight [1448/49] Funding Source: researchfish
- Medical Research Council [MR/J004553/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10074, NF-SI-0508-10130] Funding Source: researchfish
- Wellcome Trust [086128/Z/08/Z] Funding Source: Wellcome Trust
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Despite very different aetiologies, age-related macular degeneration (AMD) and most inherited retinal disorders culminate in the same final common pathway, loss of the light-sensitive photoreceptors. There are few clinical treatments and none can reverse the loss of vision. Photoreceptor replacement by transplantation is proposed as a broad treatment strategy applicable to all degenerations. The past decade has seen a number of landmark achievements in this field, which together provide strong justification for continuing investigation into photoreceptor replacement strategies. These include proof of principle for restoring vision by rod-photoreceptor transplantation in mice with congenital stationary night blindness and advances in stem cell biology, which have led to the generation of complete optic structures in vitro from embryonic stem cells. The latter represents enormous potential for generating suitable and renewable donor cells with which to achieve the former. However, there are still challenges presented by the degenerating recipient retinal environment that must be addressed as we move to translating these technologies towards clinical application. (C) 2014 The Author. Published by Elsevier Inc. All rights reserved.
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