Journal
BIOTECHNOLOGY ADVANCES
Volume 32, Issue 7, Pages 1216-1236Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2014.07.005
Keywords
Metabolic engineering; Polylactide; Cellulose; Ethanol; Butanol; Polyhydroxyalkanoates; Mannitol; GABA; Bacteriocins
Categories
Funding
- University of Torino-Regione Piemonte
- Carbios
- Biopole Clermont-Limagne
- Saint-Beauzire (France)
- Israel Ministry of Science Technology and Space [362043313]
- Israel Ministry of Agriculture and Rural Development [362042613]
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Lactic acid bacteria (LAB) have long been used in industrial applications mainly as starters for food fermentation or as biocontrol agents or as probiotics. However, LAB possess several characteristics that render them among the most promising candidates for use in future biorefineries in converting plant-derived biomass either from dedicated crops or from municipal/industrial solid wastes into biofuels and high value-added products. Lactic acid, their main fermentation product, is an attractive building block extensively used by the chemical industry, owing to the potential for production of polylactides as biodegradable and biocompatible plastic alternative to polymers derived from petrochemicals. LA is but one of many high-value compounds which can be produced by LAB fermentation, which also include biofuels such as ethanol and butanol, biodegradable plastic polymers, exopolysaccharides, antimicrobial agents, health-promoting substances and nutraceuticals. Furthermore, several LAB strains have ascertained probiotic properties, and their biomass can be considered a high-value product. The present contribution aims to provide an extensive overview of the main industrial applications of LAB and future perspectives concerning their utilization in biorefineries. Strategies will be described in detail for developing LAB strains with broader substrate metabolic capacity for fermentation of cheaper biomass. (C) 2014 Elsevier Inc. All rights reserved.
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