Journal
BIOTECHNOLOGY ADVANCES
Volume 32, Issue 6, Pages 1123-1132Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2014.03.009
Keywords
Epigenetics; Natural compounds; Cell death; Proliferation; Clinical trials; Cancer therapy; Cancer prevention
Categories
Funding
- Action Lions Vaincre le Cancer
- Recherche Cancer et Sang foundation
- Recherches Scientifiques Luxembourg association
- Een Haerz fir kriibskrank Kanner association
- Action LIONS Vaincre le Cancer association
- Televie Luxembourg
- National Research Foundation of Korea (NRF) - Korea government, Ministry of Science, ICT & Future Planning (MSIP) [2011-0030001]
- National Research Foundation of Korea [2011-0030001] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Carcinogenesis is a complex and multistep process that involves the accumulation of successive transformational events driven by genetic mutations and epigenetic alterations that affect major cellular processes and pathways such as proliferation, differentiation, invasion and survival. Massive deregulation of all components of the epigenetic machinery is a hallmark of cancer. These alterations affect normal gene regulation and impede normal cellular processes including cell cycle, DNA repair, cell growth, differentiation and apoptosis. Since epigenetic alterations appear early in cancer development and represent potentially initiating events during carcinogenesis, they are considered as promising targets for anti-cancer interventions by chemopreventive and chemotherapeutic strategies using epigenetically active agents. In this field, plant-derived compounds have shown promise. Here, we will give an overview of plant-derived compounds displaying anticancer properties that interfere with the epigenetic machinery. (C) 2014 Elsevier Inc. All rights reserved.
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