Journal
BIOTECHNOLOGY ADVANCES
Volume 32, Issue 2, Pages 347-365Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2013.11.007
Keywords
Cell alignment; Tissue engineering; Mechanical loading; Topographical patterning; Surface chemical treatment
Categories
Funding
- Major International Joint Research Program of China [11120101002]
- National 111 Project of China Key (Key grant) Project of Chinese Ministry of Education [B06024, 313045]
- International Cooperation and Exchange of the National Natural Science Foundation of China [31050110125]
- International Science & Technology Cooperation Program of China [2013DFG02930]
- China Postdoctoral Science Foundation [2013M540742]
- China Young 1000-Talent Program
- Program for New Century Excellent Talents in University
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Cell alignment plays a critical role in various cell behaviors including cytoskeleton reorganization, membrane protein relocation, nucleus gene expression, and ECM remodeling. Cell alignment is also known to exert significant effects on tissue regeneration (e.g., neuron) and modulate mechanical properties of tissues including skeleton, cardiac muscle and tendon. Therefore, it is essential to engineer cell alignment in vitro for biomechanics, cell biology, tissue engineering and regenerative medicine applications. With advances in nano- and micro-scale technologies, a variety of approaches have been developed to engineer cell alignment in vitro, including mechanical loading, topographical patterning, and surface chemical treatment In this review, we first present alignments of various cell types and their functionality in different tissues in vivo including muscle and nerve tissues. Then, we provide an overview of recent approaches for engineering cell alignment in vitro. Finally, concluding remarks and perspectives are addressed for future improvement of engineering cell alignment (C) 2013 Elsevier Inc All rights reserved.
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