Journal
BIOTECHNOLOGY ADVANCES
Volume 32, Issue 4, Pages 844-852Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2013.08.001
Keywords
Dendrimer; Nanovector; RNAi therapeutics; RNA interference; Gene silencing
Categories
Funding
- international ERA-Net EURONANOMED European Research project DENANORNA, Ministry of Science and Technology of China [2012AA022501]
- PACA Canceropole
- INCa
- Wuhan University
- Aix-Marseille University
- CNRS
- INSERM
- Association pour la Recherche sur les Tumeurs de la Prostate
- China Scholarship Council
- European COST Action [TD0802]
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RNAi-based nucleic acid molecules have attracted considerable attention as compelling therapeutics providing safe and competent delivery systems are available. Dendrimers are emerging as appealing nanocarriers for nucleic acid delivery thanks to their unique well-defined architecture and the resulting cooperativity and multivalency confined within a nanostructure. The present review offers a brief overview of the structurally flexible triethanolamine-core poly(amidoamine) (PAMAM) dendrimers developed in our group as nanovectors for the delivery of RNAi therapeutics. Their excellent activity for delivering different RNAi therapeutics in various disease models in vitro and in vivo will be highlighted here. (C) 2013 Elsevier Inc. All rights reserved.
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