Journal
BIOTECHNOLOGY ADVANCES
Volume 32, Issue 7, Pages 1245-1255Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2014.07.003
Keywords
In-situ product recovery (ISPR); ISPR-coupled whole-cell bioprocess; Microbial biotransformations
Categories
Funding
- 7th Framework Programme of the European Union [289194]
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The review presents the state-of-the-art in the applications of in-situ product recovery (ISPR) in whole-cell biotechnology over the last 10 years. It summarizes various ISPR-integrated fermentation processes for the production of a wide spectrum of bio-based products. A critical assessment of the performance of various ISPR concepts with respect to the degree of product enrichment, improved productivity, reduced process flows and increased yields is provided. Requirements to allow a successful industrial implementation of ISPR are also discussed. Finally, supporting technologies such as online monitoring, mathematical modeling and use of recombinant microorganisms with ISPR are presented. (C) 2014 Elsevier Inc. All rights reserved.
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