Journal
BIOTECHNOLOGY ADVANCES
Volume 32, Issue 3, Pages 615-622Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2014.04.001
Keywords
Muconic acid; Bio-based chemical; Rational design; Microbial cell factory; Systems metabolic engineering
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Funding
- National Natural Science Foundation of China [31360207]
- Guangxi Science Foundation [2012GXNSFBA053063]
- Guangxi Academy of Sciences [12YJ25SW01]
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Muconic acid (MA), a high value-added bio-product with reactive dicarboxylic groups and conjugated double bonds, has garnered increasing interest owing to its potential applications in the manufacture of new functional resins, bio-plastics, food additives, agrochemicals, and pharmaceuticals. At the very least. MA can be used to produce commercially important bulk chemicals such as adipic acid, terephthalic acid and trimellitic acid. Recently, great progress has been made in the development of biotechnological routes for MA production. This present review provides a comprehensive and systematic overview of recent advances and challenges in biotechnological production of MA. Various biological methods are summarized and compared, and their constraints and possible solutions are also described. Finally, the future prospects are discussed with respect to the current state, challenges, and trends in this field, and the guidelines to develop high-performance microbial cell factories are also proposed for the MA production by systems metabolic engineering. (C) 2014 Elsevier Inc. All rights reserved.
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