Journal
BIOTECHNOLOGY ADVANCES
Volume 31, Issue 8, Pages 1172-1186Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biotechadv.2013.02.005
Keywords
Surface imprinting; Protein; Nanomaterials; Recognition
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Funding
- Office of Science, Office of Basic Energy Sciences, Scientific User Facilities Division of the U.S. Department of Energy [DE-AC02-05CH11231]
- special assistance of 973 programs [2013CB733600, 2007CB714300, 2011CB710805, 2007CB714302-2]
- National Natural Science Foundation of China [20806006, 21076009, 20636010]
- 863 program [2006AA020102, 2007AA10040]
- Beijing Educational Committee Joint Construction
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This review article summarizes the preparation of polymers imprinted with proteins that exhibit antibody-like specificity due to the presence of well-defined recognition sites. We present the newest developments concerned with use of nanomaterials, such as magnetic and silica nanoparticles, nanowires, carbon nanotubes, and quantum dots as supports enabling the preparation of protein-imprinted polymers via surface imprinting techniques. As an alternative receptor-like synthetic materials, these conjugates are attracting a great deal of interest in various fields including proteomics, genomics, and fabrication of selective sensors. However, imprinting of large biomacromolecules such as proteins still remains a challenge due to the inherent limitations related to protein properties. In the text below, we also describe examples of applications focused on selective recognition of biomacromolecules. (C) 2013 Elsevier Inc. All rights reserved.
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